Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

A population of NK cells expressing the activating receptor NKG2C and the maturation marker CD57 expands in response to human CMV (HCMV) infection. CD3(–)CD56(dim)CD57(+)NKG2C(+) NK cells are similar to CD8(+) memory T cells with rapid and robust effector function upon restimulation, persistence, an...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Merino, Aimee, Zhang, Bin, Dougherty, Philip, Luo, Xianghua, Wang, Jinhua, Blazar, Bruce R., Miller, Jeffrey S., Cichocki, Frank
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715389/
https://ncbi.nlm.nih.gov/pubmed/31211698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125916
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