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Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming
A population of NK cells expressing the activating receptor NKG2C and the maturation marker CD57 expands in response to human CMV (HCMV) infection. CD3(–)CD56(dim)CD57(+)NKG2C(+) NK cells are similar to CD8(+) memory T cells with rapid and robust effector function upon restimulation, persistence, an...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6715389/ https://ncbi.nlm.nih.gov/pubmed/31211698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125916 |
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