Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

The mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human NK cells selectively lacking expression of signaling proteins after human cytomegalovirus (HCMV) infection. The absence of B and m...

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Publicado en:Immunity
Main Authors: Schlums, Heinrich, Cichocki, Frank, Tesi, Bianca, Theorell, Jakob, Beziat, Vivien, Holmes, Tim D., Han, Hongya, Chiang, Samuel C.C., Foley, Bree, Mattsson, Kristin, Larsson, Stella, Schaffer, Marie, Malmberg, Karl-Johan, Ljunggren, Hans-Gustaf, Miller, Jeffrey S., Bryceson, Yenan T.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612277/
https://ncbi.nlm.nih.gov/pubmed/25786176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.02.008
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