IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus infections for which no specific approved drug or vaccine is available. The Middle East respiratory syndrome–coronaviru...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Channappanavar, Rudragouda, Fehr, Anthony R., Zheng, Jian, Wohlford-Lenane, Christine, Abrahante, Juan E., Mack, Matthias, Sompallae, Ramakrishna, McCray, Paul B., Meyerholz, David K., Perlman, Stanley
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715373/
https://ncbi.nlm.nih.gov/pubmed/31355779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126363
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