Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo

Overexpression or activation of AKT is very well known to control cell growth, survival and gene expression in solid tumors. Oridonin, an inflammatory medical and diterpenoid compound isolated from Rabdosia rubescens, has exhibited various pharmacological and physiological properties, including anti...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Song, Mengqiu, Liu, Xuejiao, Liu, Kangdong, Zhao, Ran, Huang, Hai, Shi, Yuanyuan, Zhang, Man, Zhou, Silei, Xie, Hua, Chen, Hanyong, Li, Yin, Zheng, Yan, Wu, Qiong, Liu, Fangfang, Li, Enmin, Bode, Ann M., Dong, Zigang, Lee, Mee-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715294/
https://ncbi.nlm.nih.gov/pubmed/29695636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0823
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