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Reversal of Factor Xa Inhibitors by Andexanet Alfa May Increase Thrombogenesis Compared to Pretreatment Values

Recombinant coagulation factor Xa (FXa), inactivated Zh-zo, also known as andexanet alfa (AA), is a modified version of human FXa that has been developed to neutralize FXa inhibitors. We studied the reversal effect of AA for these inhibitors in various anticoagulant and thrombin generation (TG) assa...

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Vydáno v:Clin Appl Thromb Hemost
Hlavní autoři: Siddiqui, Fakiha, Tafur, Alfonso, Ramacciotti, Lorenzo Storino, Jeske, Walter, Hoppensteadt, Debra, Ramacciotti, Eduardo, Iqbal, Omer, Fareed, Jawed
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714992/
https://ncbi.nlm.nih.gov/pubmed/31298056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1076029619863493
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