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Reversal of Factor Xa Inhibitors by Andexanet Alfa May Increase Thrombogenesis Compared to Pretreatment Values

Recombinant coagulation factor Xa (FXa), inactivated Zh-zo, also known as andexanet alfa (AA), is a modified version of human FXa that has been developed to neutralize FXa inhibitors. We studied the reversal effect of AA for these inhibitors in various anticoagulant and thrombin generation (TG) assa...

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Detalhes bibliográficos
Publicado no:Clin Appl Thromb Hemost
Main Authors: Siddiqui, Fakiha, Tafur, Alfonso, Ramacciotti, Lorenzo Storino, Jeske, Walter, Hoppensteadt, Debra, Ramacciotti, Eduardo, Iqbal, Omer, Fareed, Jawed
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714992/
https://ncbi.nlm.nih.gov/pubmed/31298056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1076029619863493
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