Mannose 6‐phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease

In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6‐phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation becaus...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Godefroy, Anastasia, Daurat, Morgane, Da Silva, Afitz, Basile, Ilaria, El Cheikh, Khaled, Caillaud, Catherine, Sacconi, Sabrina, Schoser, Benedikt, Charbonné, Henry‐Vincent, Gary‐Bobo, Magali, Morère, Alain, Garcia, Marcel, Maynadier, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714136/
https://ncbi.nlm.nih.gov/pubmed/31293082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14516
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