Mannose 6‐phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease

In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6‐phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation becaus...

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Библиографические подробности
Опубликовано в: :J Cell Mol Med
Главные авторы: Godefroy, Anastasia, Daurat, Morgane, Da Silva, Afitz, Basile, Ilaria, El Cheikh, Khaled, Caillaud, Catherine, Sacconi, Sabrina, Schoser, Benedikt, Charbonné, Henry‐Vincent, Gary‐Bobo, Magali, Morère, Alain, Garcia, Marcel, Maynadier, Marie
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Short Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714136/
https://ncbi.nlm.nih.gov/pubmed/31293082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14516
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