Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex

Understanding transcriptional changes engaged in stress resilience may reveal novel antidepressant targets. Here, we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstud...

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Published in:Nat Neurosci
Main Authors: Lorsch, Zachary S., Hamilton, Peter J., Ramakrishnan, Aarthi, Parise, Eric M., Salery, Marine, Wright, William J., Lepack, Ashley E., Mews, Philipp, Issler, Orna, McKenzie, Andrew, Zhou, Xianxiao, Parise, Lyonna F., Pirpinias, Stephen T., Torres, Idelisse Ortiz, Kronman, Hope G., Montgomery, Sarah E., Loh, Yong-Hwee Eddie, Labonté, Benoit, Conkey, Andrew, Symonds, Ann E., Neve, Rachael L., Turecki, Gustavo, Maze, Ian, Dong, Yan, Zhang, Bin, Shen, Li, Bagot, Rosemary C., Nestler, Eric J.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713580/
https://ncbi.nlm.nih.gov/pubmed/31427770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0462-8
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