The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide

In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting intermediary metabolism. Nitric oxide is known to inhibit complex IV of the electron transport chain and aconitase of the Krebs cycle. Non-β...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Cell Biol
Главные авторы: Oleson, Bryndon J., Broniowska, Katarzyna A., Yeo, Chay Teng, Flancher, Michael, Naatz, Aaron, Hogg, Neil, Tarakanova, Vera L., Corbett, John A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712938/
https://ncbi.nlm.nih.gov/pubmed/31235477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00153-19
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы