The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide

In this report, we show that nitric oxide suppresses DNA damage response (DDR) signaling in the pancreatic β-cell line INS 832/13 and rat islets by inhibiting intermediary metabolism. Nitric oxide is known to inhibit complex IV of the electron transport chain and aconitase of the Krebs cycle. Non-β...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Oleson, Bryndon J., Broniowska, Katarzyna A., Yeo, Chay Teng, Flancher, Michael, Naatz, Aaron, Hogg, Neil, Tarakanova, Vera L., Corbett, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712938/
https://ncbi.nlm.nih.gov/pubmed/31235477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00153-19
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