Dinaciclib enhances natural killer cell cytotoxicity against acute myelogenous leukemia

Dinaciclib enhances NK-cell activity against leukemia cells in preclinical AML models. Enhanced NK-cell activation by dinaciclib-treated AML is associated with downregulation of inhibitory NK ligand HLA-E on leukemia cells.

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Yun, Hyun Don, Schirm, Dawn K., Felices, Martin, Miller, Jeffrey S., Eckfeldt, Craig E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Stimulus Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712524/
https://ncbi.nlm.nih.gov/pubmed/31416822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000064
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