Significantly increased anti‐tumor activity of carcinoembryonic antigen‐specific chimeric antigen receptor T cells in combination with recombinant human IL‐12

BACKGROUND AIMS: Chimeric antigen receptor T cells (CAR‐T cells) have been successfully used in treatments of hematological tumors, however, their anti‐tumor activity in solid tumor treatments was limited. As IL‐12 increases T‐cell immune functions, we designed carcinoembryonic antigen (CEA) specifi...

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Publicado en:Cancer Med
Main Authors: Chi, Xiaowei, Yang, Peiwei, Zhang, Erhao, Gu, Jieyi, Xu, Hui, Li, Mengwei, Gao, Xinmei, Li, Xin, Zhang, Yinan, Xu, Hanmei, Hu, Jialiang
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
Assuntos:
Cancer Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712469/
https://ncbi.nlm.nih.gov/pubmed/31237116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2361
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