Significantly increased anti‐tumor activity of carcinoembryonic antigen‐specific chimeric antigen receptor T cells in combination with recombinant human IL‐12

BACKGROUND AIMS: Chimeric antigen receptor T cells (CAR‐T cells) have been successfully used in treatments of hematological tumors, however, their anti‐tumor activity in solid tumor treatments was limited. As IL‐12 increases T‐cell immune functions, we designed carcinoembryonic antigen (CEA) specifi...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Med
Hauptverfasser: Chi, Xiaowei, Yang, Peiwei, Zhang, Erhao, Gu, Jieyi, Xu, Hui, Li, Mengwei, Gao, Xinmei, Li, Xin, Zhang, Yinan, Xu, Hanmei, Hu, Jialiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712469/
https://ncbi.nlm.nih.gov/pubmed/31237116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2361
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