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Albumin evokes Ca(2+)-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin
In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production an...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6711968/ https://ncbi.nlm.nih.gov/pubmed/31455864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48716-x |
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