Incorporation of a chiral gem-disubstituted nitrogen heterocycle yields an oxazolidinone antibiotic with reduced mitochondrial toxicity

gem-Disubstituted N-heterocycles are rarely found in drugs, despite their potential to improve the drug-like properties of small molecule pharmaceuticals. Linezolid, a morpholine heterocycle-containing oxazolidinone antibiotic, exhibits significant side effects associated with human mitochondrial pr...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Sun, Alexander W., Bulterys, Philip L., Bartberger, Michael D., Jorth, Peter A., O’Boyle, Brendan M., Virgil, Scott C., Miller, Jeff F., Stoltz, Brian M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711789/
https://ncbi.nlm.nih.gov/pubmed/31383589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.07.024
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