FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding

FcγRIIB binding to its ligand suppresses immune cell activation. A single-nucleotide polymorphic (SNP) change, I232T, in the transmembrane (TM) domain of FcγRIIB loses its suppressive function, which is clinically associated with systemic lupus erythematosus (SLE). Previously, we reported that I232T...

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Pubblicato in:eLife
Autori principali: Hu, Wei, Zhang, Yong, Sun, Xiaolin, Zhang, Tongtong, Xu, Liling, Xie, Hengyi, Li, Zhanguo, Liu, Wanli, Lou, Jizhong, Chen, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Immunology and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711707/
https://ncbi.nlm.nih.gov/pubmed/31343409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46689
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