Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232

FcγRIIB functions to suppress the activation of immune cells. A single-nucleotide polymorphism in the transmembrane (TM) domain of FcγRIIB, FcγRIIB-T232, is associated with lupus. In this study, we investigated the pathogenic mechanism of FcγRIIB-T232 at both functional and structural levels. Our re...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Xu, Liling, Xia, Mengdie, Guo, Jun, Sun, Xiaolin, Li, Hua, Xu, Chenguang, Gu, Xiaomei, Zhang, Haowen, Yi, Junyang, Fang, Yan, Xie, Hengyi, Wang, Jing, Shen, Zhixun, Xue, Boxin, Sun, Yujie, Meckel, Tobias, Chen, Ying-Hua, Hu, Zhibin, Li, Zhanguo, Xu, Chenqi, Gong, Haipeng, Liu, Wanli
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110019/
https://ncbi.nlm.nih.gov/pubmed/27799621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160528
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