Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1

Nucleophosmin 1 (NPM1) is an oligomeric, nucleolar phosphoprotein that functions as a molecular chaperone for both proteins and nucleic acids. NPM1 is mutated in approximately one-third of patients with AML. The mutant NPM1c+ contains a 4-base insert that results in extra C-terminal residues encodin...

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Bibliografski detalji
Izdano u:Blood
Glavni autori: Balusu, Ramesh, Fiskus, Warren, Rao, Rekha, Chong, Daniel G., Nalluri, Srilatha, Mudunuru, Uma, Ma, Hongwei, Chen, Lei, Venkannagari, Sreedhar, Ha, Kyungsoo, Abhyankar, Sunil, Williams, Casey, McGuirk, Joseph, Khoury, Hanna Jean, Ustun, Celalettin, Bhalla, Kapil N.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Myeloid Neoplasia
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710561/
https://ncbi.nlm.nih.gov/pubmed/21719597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-309674
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