Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

The small GTPase KRAS, which is frequently mutated in human cancers, must be localized to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C-terminal membrane anchor exhibits exquisite lipid-binding specificity for select species of phosphatidylserine (PtdSer). We,...

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Detalles Bibliográficos
Publicado en:Life Sci Alliance
Main Authors: Kattan, Walaa E, Chen, Wei, Ma, Xiaoping, Lan, Tien Hung, van der Hoeven, Dharini, van der Hoeven, Ransome, Hancock, John F
Formato: Artigo
Idioma:Inglês
Publicado: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709719/
https://ncbi.nlm.nih.gov/pubmed/31451509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900431
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