Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

The small GTPase KRAS, which is frequently mutated in human cancers, must be localized to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C-terminal membrane anchor exhibits exquisite lipid-binding specificity for select species of phosphatidylserine (PtdSer). We,...

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Dettagli Bibliografici
Pubblicato in:Life Sci Alliance
Autori principali: Kattan, Walaa E, Chen, Wei, Ma, Xiaoping, Lan, Tien Hung, van der Hoeven, Dharini, van der Hoeven, Ransome, Hancock, John F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Life Science Alliance LLC 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709719/
https://ncbi.nlm.nih.gov/pubmed/31451509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900431
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