Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

The small GTPase KRAS, which is frequently mutated in human cancers, must be localized to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C-terminal membrane anchor exhibits exquisite lipid-binding specificity for select species of phosphatidylserine (PtdSer). We,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Life Sci Alliance
Päätekijät: Kattan, Walaa E, Chen, Wei, Ma, Xiaoping, Lan, Tien Hung, van der Hoeven, Dharini, van der Hoeven, Ransome, Hancock, John F
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Life Science Alliance LLC 2019
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709719/
https://ncbi.nlm.nih.gov/pubmed/31451509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900431
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