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Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission
Ras proteins regulate signaling pathways important for cell growth, differentiation, and survival. Oncogenic mutant Ras proteins are commonly expressed in human tumors, with mutations of the K-Ras isoform being most prevalent. To be active, K-Ras must undergo posttranslational processing and associa...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554123/ https://ncbi.nlm.nih.gov/pubmed/23129805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00884-12 |
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