Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission

Ras proteins regulate signaling pathways important for cell growth, differentiation, and survival. Oncogenic mutant Ras proteins are commonly expressed in human tumors, with mutations of the K-Ras isoform being most prevalent. To be active, K-Ras must undergo posttranslational processing and associa...

Full description

Saved in:
Bibliographic Details
Main Authors: van der Hoeven, Dharini, Cho, Kwang-jin, Ma, Xiaoping, Chigurupati, Sravanthi, Parton, Robert G., Hancock, John F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554123/
https://ncbi.nlm.nih.gov/pubmed/23129805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00884-12
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items