Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction

The spatial organization of Ras proteins into nanoclusters on the inner leaflet of the plasma membrane is essential for high fidelity signaling through the MAPK pathway. Here we identify two selective regulators of K-Ras nanoclustering from a proteomic screen for K-Ras interacting proteins. Nucleoph...

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Bibliographische Detailangaben
Hauptverfasser: Inder, Kerry L., Lau, Chiyan, Loo, Dorothy, Chaudhary, Natasha, Goodall, Andrew, Martin, Sally, Jones, Alun, van der Hoeven, Dharini, Parton, Robert G., Hill, Michelle M., Hancock, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788890/
https://ncbi.nlm.nih.gov/pubmed/19661056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001537
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