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Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs

The Ras/Raf/MEK/ERK (MAPK) pathway directs multiple cell fate decisions within a single cell. How different system outputs are generated is unknown. Here we explore whether activating the MAPK module from different membrane environments can rewire system output. We identify two classes of nanoscale...

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Detalhes bibliográficos
Main Authors: Inder, Kerry, Harding, Angus, Plowman, Sarah J., Philips, Mark R., Parton, Robert G., Hancock, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575182/
https://ncbi.nlm.nih.gov/pubmed/18784252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-04-0407
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