Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction

The spatial organization of Ras proteins into nanoclusters on the inner leaflet of the plasma membrane is essential for high fidelity signaling through the MAPK pathway. Here we identify two selective regulators of K-Ras nanoclustering from a proteomic screen for K-Ras interacting proteins. Nucleoph...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Inder, Kerry L., Lau, Chiyan, Loo, Dorothy, Chaudhary, Natasha, Goodall, Andrew, Martin, Sally, Jones, Alun, van der Hoeven, Dharini, Parton, Robert G., Hill, Michelle M., Hancock, John F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mechanisms of Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788890/
https://ncbi.nlm.nih.gov/pubmed/19661056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001537
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