Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum

The chloroquine resistance transporter PfCRT of the human malaria parasite Plasmodium falciparum confers resistance to the former first-line antimalarial drug chloroquine, and it modulates the responsiveness to a wide range of quinoline and quinoline-like compounds. PfCRT is post-translationally mod...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Sanchez, Cecilia P., Moliner Cubel, Sonia, Nyboer, Britta, Jankowska-Döllken, Monika, Schaeffer-Reiss, Christine, Ayoub, Daniel, Planelles, Gabrielle, Lanzer, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709616/
https://ncbi.nlm.nih.gov/pubmed/31285265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009464
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