In Vivo Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models

The pharmacokinetic (PK) and pharmacodynamic (PD) parameters which correlated with the in vivo efficacy of cefiderocol were evaluated using neutropenic murine thigh and lung infection models in which the infections were caused by a variety of Gram-negative bacilli. The dose fractionation study using...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Nakamura, Rio, Ito-Horiyama, Tsukasa, Takemura, Miki, Toba, Shinsuke, Matsumoto, Shuhei, Ikehara, Tatsuya, Tsuji, Masakatsu, Sato, Takafumi, Yamano, Yoshinori
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709502/
https://ncbi.nlm.nih.gov/pubmed/31262762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02031-18
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