In Vivo Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models

The pharmacokinetic (PK) and pharmacodynamic (PD) parameters which correlated with the in vivo efficacy of cefiderocol were evaluated using neutropenic murine thigh and lung infection models in which the infections were caused by a variety of Gram-negative bacilli. The dose fractionation study using...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Nakamura, Rio, Ito-Horiyama, Tsukasa, Takemura, Miki, Toba, Shinsuke, Matsumoto, Shuhei, Ikehara, Tatsuya, Tsuji, Masakatsu, Sato, Takafumi, Yamano, Yoshinori
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709502/
https://ncbi.nlm.nih.gov/pubmed/31262762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02031-18
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