Siderophore Cephalosporin Cefiderocol Utilizes Ferric Iron Transporter Systems for Antibacterial Activity against Pseudomonas aeruginosa

Cefiderocol (S-649266) is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety at the third-position side chain. The in vitro activity of cefiderocol against Pseudomonas aeruginosa was enhanced under iron-depleted conditions, whereas that of ceftazidime was not affected. Th...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Ito, Akinobu, Nishikawa, Toru, Matsumoto, Shuhei, Yoshizawa, Hidenori, Sato, Takafumi, Nakamura, Rio, Tsuji, Masakatsu, Yamano, Yoshinori
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119021/
https://ncbi.nlm.nih.gov/pubmed/27736756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01405-16
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