Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases

To better understand the antibacterial activity of S-649266 against carbapenemase producers, its stability against clinically relevant carbapenemases was investigated. The catalytic efficiencies (k(cat)/K(m)) of IMP-1, VIM-2, and L1 for S-649266 were 0.0048, 0.0050, and 0.024 μM(−1) s(−1), respectiv...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Ito-Horiyama, Tsukasa, Ishii, Yoshikazu, Ito, Akinobu, Sato, Takafumi, Nakamura, Rio, Fukuhara, Norio, Tsuji, Masakatsu, Yamano, Yoshinori, Yamaguchi, Keizo, Tateda, Kazuhiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Mechanisms of Resistance
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914688/
https://ncbi.nlm.nih.gov/pubmed/27139465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03098-15
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