Auranofin Activity Exposes Thioredoxin Reductase as a Viable Drug Target in Mycobacterium abscessus

Nontuberculous mycobacteria (NTM) are highly drug-resistant, opportunistic pathogens that can cause pulmonary disease. The outcomes of the currently recommended treatment regimens are poor, especially for Mycobacterium abscessus. New or repurposed drugs are direly needed. Auranofin, a gold-based ant...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Ruth, Mike Marvin, van Rossum, Mara, Koeken, Valerie A. C. M., Pennings, Lian J., Svensson, Elin M., Ruesen, Carolien, Bowles, Edmee C., Wertheim, Heiman F. L., Hoefsloot, Wouter, van Ingen, Jakko
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Susceptibility
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709478/
https://ncbi.nlm.nih.gov/pubmed/31262763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00449-19
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