Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance

Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) is challenging partly due to high efflux pump expression. Thioridazine might block these efflux pumps. We explore the efficacy of thioridazine against M. avium isolates using MICs, time-kill combination assays, ex vivo macrophage in...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ruth, Mike Marvin, Pennings, Lian J., Koeken, Valerie A. C. M., Schildkraut, Jodie A., Hashemi, Aria, Wertheim, Heiman F. L., Hoefsloot, Wouter, van Ingen, Jakko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318027/
https://ncbi.nlm.nih.gov/pubmed/32312774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00181-20
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