Auranofin Activity Exposes Thioredoxin Reductase as a Viable Drug Target in Mycobacterium abscessus

Nontuberculous mycobacteria (NTM) are highly drug-resistant, opportunistic pathogens that can cause pulmonary disease. The outcomes of the currently recommended treatment regimens are poor, especially for Mycobacterium abscessus. New or repurposed drugs are direly needed. Auranofin, a gold-based ant...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Ruth, Mike Marvin, van Rossum, Mara, Koeken, Valerie A. C. M., Pennings, Lian J., Svensson, Elin M., Ruesen, Carolien, Bowles, Edmee C., Wertheim, Heiman F. L., Hoefsloot, Wouter, van Ingen, Jakko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Susceptibility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709478/
https://ncbi.nlm.nih.gov/pubmed/31262763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00449-19
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