Auranofin Activity Exposes Thioredoxin Reductase as a Viable Drug Target in Mycobacterium abscessus

Nontuberculous mycobacteria (NTM) are highly drug-resistant, opportunistic pathogens that can cause pulmonary disease. The outcomes of the currently recommended treatment regimens are poor, especially for Mycobacterium abscessus. New or repurposed drugs are direly needed. Auranofin, a gold-based ant...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ruth, Mike Marvin, van Rossum, Mara, Koeken, Valerie A. C. M., Pennings, Lian J., Svensson, Elin M., Ruesen, Carolien, Bowles, Edmee C., Wertheim, Heiman F. L., Hoefsloot, Wouter, van Ingen, Jakko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709478/
https://ncbi.nlm.nih.gov/pubmed/31262763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00449-19
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