Auranofin Activity Exposes Thioredoxin Reductase as a Viable Drug Target in Mycobacterium abscessus

Nontuberculous mycobacteria (NTM) are highly drug-resistant, opportunistic pathogens that can cause pulmonary disease. The outcomes of the currently recommended treatment regimens are poor, especially for Mycobacterium abscessus. New or repurposed drugs are direly needed. Auranofin, a gold-based ant...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Ruth, Mike Marvin, van Rossum, Mara, Koeken, Valerie A. C. M., Pennings, Lian J., Svensson, Elin M., Ruesen, Carolien, Bowles, Edmee C., Wertheim, Heiman F. L., Hoefsloot, Wouter, van Ingen, Jakko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2019
Pynciau:
Susceptibility
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709478/
https://ncbi.nlm.nih.gov/pubmed/31262763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00449-19
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