Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations

Multitargeting antibiotics, i.e., single compounds capable of inhibiting two or more bacterial targets, are generally considered to be a promising therapeutic strategy against resistance evolution. The rationale for this theory is that multitargeting antibiotics demand the simultaneous acquisition o...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Szili, Petra, Draskovits, Gábor, Révész, Tamás, Bogár, Ferenc, Balogh, Dávid, Martinek, Tamás, Daruka, Lejla, Spohn, Réka, Vásárhelyi, Bálint Márk, Czikkely, Márton, Kintses, Bálint, Grézal, Gábor, Ferenc, Györgyi, Pál, Csaba, Nyerges, Ákos
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709476/
https://ncbi.nlm.nih.gov/pubmed/31235632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00207-19
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