Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance

Antibiotic development is frequently plagued by the rapid emergence of drug resistance. However, assessing the risk of resistance development in the preclinical stage is difficult. Standard laboratory evolution approaches explore only a small fraction of the sequence space and fail to identify excee...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nyerges, Ákos, Csörgő, Bálint, Draskovits, Gábor, Kintses, Bálint, Szili, Petra, Ferenc, Györgyi, Révész, Tamás, Ari, Eszter, Nagy, István, Bálint, Balázs, Vásárhelyi, Bálint Márk, Bihari, Péter, Számel, Mónika, Balogh, Dávid, Papp, Henrietta, Kalapis, Dorottya, Papp, Balázs, Pál, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016788/
https://ncbi.nlm.nih.gov/pubmed/29871954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801646115
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