Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance

Antibiotic development is frequently plagued by the rapid emergence of drug resistance. However, assessing the risk of resistance development in the preclinical stage is difficult. Standard laboratory evolution approaches explore only a small fraction of the sequence space and fail to identify excee...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nyerges, Ákos, Csörgő, Bálint, Draskovits, Gábor, Kintses, Bálint, Szili, Petra, Ferenc, Györgyi, Révész, Tamás, Ari, Eszter, Nagy, István, Bálint, Balázs, Vásárhelyi, Bálint Márk, Bihari, Péter, Számel, Mónika, Balogh, Dávid, Papp, Henrietta, Kalapis, Dorottya, Papp, Balázs, Pál, Csaba
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016788/
https://ncbi.nlm.nih.gov/pubmed/29871954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801646115
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