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Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance

Antibiotic development is frequently plagued by the rapid emergence of drug resistance. However, assessing the risk of resistance development in the preclinical stage is difficult. Standard laboratory evolution approaches explore only a small fraction of the sequence space and fail to identify excee...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Nyerges, Ákos, Csörgő, Bálint, Draskovits, Gábor, Kintses, Bálint, Szili, Petra, Ferenc, Györgyi, Révész, Tamás, Ari, Eszter, Nagy, István, Bálint, Balázs, Vásárhelyi, Bálint Márk, Bihari, Péter, Számel, Mónika, Balogh, Dávid, Papp, Henrietta, Kalapis, Dorottya, Papp, Balázs, Pál, Csaba
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016788/
https://ncbi.nlm.nih.gov/pubmed/29871954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801646115
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