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Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance
Antibiotic development is frequently plagued by the rapid emergence of drug resistance. However, assessing the risk of resistance development in the preclinical stage is difficult. Standard laboratory evolution approaches explore only a small fraction of the sequence space and fail to identify excee...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6016788/ https://ncbi.nlm.nih.gov/pubmed/29871954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801646115 |
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