Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues

Repetitive sequences are hotspots of evolution at multiple levels. However, due to difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content, beyond m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Persi, Erez, Prandi, Davide, Wolf, Yuri I., Pozniak, Yair, Barnabas, Georgina D., Levanon, Keren, Barshack, Iris, Barbieri, Christopher, Gasperini, Paola, Beltran, Himisha, Faltas, Bishoy M., Rubin, Mark A., Geiger, Tamar, Koonin, Eugene V., Demichelis, Francesca, Horn, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708321/
https://ncbi.nlm.nih.gov/pubmed/31387980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908790116
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