Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues

Repetitive sequences are hotspots of evolution at multiple levels. However, due to difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content, beyond m...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Persi, Erez, Prandi, Davide, Wolf, Yuri I., Pozniak, Yair, Barnabas, Georgina D., Levanon, Keren, Barshack, Iris, Barbieri, Christopher, Gasperini, Paola, Beltran, Himisha, Faltas, Bishoy M., Rubin, Mark A., Geiger, Tamar, Koonin, Eugene V., Demichelis, Francesca, Horn, David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708321/
https://ncbi.nlm.nih.gov/pubmed/31387980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908790116
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