AAV-encoded Ca(V)2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain

Transmission of pain signals from primary sensory neurons to secondary neurons of the central nervous system is critically dependent on presynaptic voltage-gated calcium channels. Calcium channel-binding domain 3 (CBD3), derived from the collapsin response mediator protein 2 (CRMP2), is a peptide ap...

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Bibliographic Details
Published in:Gene Ther
Main Authors: Yu, Hongwei, Shin, Seung Min, Xiang, Hongfei, Chao, Dongman, Cai, Yongsong, Xu, Hao, Khanna, Rajesh, Pan, Bin, Hogan, Quinn H.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707887/
https://ncbi.nlm.nih.gov/pubmed/31118475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-019-0082-7
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