Primary sensory neuron-specific interference of TRPV1 signaling by adeno-associated virus-encoded TRPV1 peptide aptamer attenuates neuropathic pain

BACKGROUND: TRPV1 (transient receptor potential vanilloid subfamily member 1) is a pain signaling channel highly expressed in primary sensory neurons. Attempts for analgesia by systemic TRPV1 blockade produce undesirable side effects, such as hyperthermia and impaired heat pain sensation. One approa...

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Publicado en:Mol Pain
Main Authors: Xiang, Hongfei, Liu, Zhen, Wang, Fei, Xu, Hao, Roberts, Christopher, Fischer, Gregory, Stucky, Cheryl L, Dean, Caron, Pan, Bin, Hogan, Quinn H, Yu, Hongwei
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486490/
https://ncbi.nlm.nih.gov/pubmed/28604222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917717040
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