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RNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration
CRISPR-based technologies have become central to genome engineering. However, CRISPR-based editing strategies are dependent on the repair of DNA breaks via endogenous DNA repair mechanisms, which increases susceptibility to unwanted mutations. Here we complement Cas9 with a recombinase's functi...
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| Veröffentlicht in: | CRISPR J |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Mary Ann Liebert, Inc., publishers
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6707420/ https://ncbi.nlm.nih.gov/pubmed/31436506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2019.0013 |
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