RNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration

CRISPR-based technologies have become central to genome engineering. However, CRISPR-based editing strategies are dependent on the repair of DNA breaks via endogenous DNA repair mechanisms, which increases susceptibility to unwanted mutations. Here we complement Cas9 with a recombinase's functi...

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Bibliografiske detaljer
Udgivet i:CRISPR J
Main Authors: Standage-Beier, Kylie, Brookhouser, Nicholas, Balachandran, Parithi, Zhang, Qi, Brafman, David A., Wang, Xiao
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2019
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707420/
https://ncbi.nlm.nih.gov/pubmed/31436506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2019.0013
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