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Targeted Large-Scale Deletion of Bacterial Genomes Using CRISPR-Nickases
[Image: see text] Programmable CRISPR-Cas systems have augmented our ability to produce precise genome manipulations. Here we demonstrate and characterize the ability of CRISPR-Cas derived nickases to direct targeted recombination of both small and large genomic regions flanked by repetitive element...
Shranjeno v:
| izdano v: | ACS Synth Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2015
|
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4655420/ https://ncbi.nlm.nih.gov/pubmed/26451892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.5b00132 |
| Oznake: |
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