Clinical Outcomes of the HIV Protease Inhibitor Nelfinavir With Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non–Small Cell Lung Cancer: A Phase 1/2 Trial

IMPORTANCE: Local failure after chemoradiotherapy (CT-RT) significantly contributes to mortality in patients with locally advanced non–small cell lung cancer (LA-NSCLC). One approach to improve local control is through targeted radiosensitization of the tumor. OBJECTIVE: To evaluate the dose-limitin...

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Dettagli Bibliografici
Pubblicato in:JAMA Oncol
Autori principali: Rengan, Ramesh, Mick, Rosemarie, Pryma, Daniel A., Lin, Lilie Leming, Christodouleas, John, Plastaras, John P., Simone, Charles B., Gupta, Anjali K., Evans, Tracey L., Stevenson, James P., Langer, Corey J., Kucharczuk, John, Friedberg, Joseph, Lam, Sarah, Patsch, Dana, Hahn, Stephen M., Maity, Amit
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2019
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707020/
https://ncbi.nlm.nih.gov/pubmed/31436839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2019.2095
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