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Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB

Mucopolysaccharide diseases (MPS) are caused by deficiency of glycosaminoglycan (GAG) degrading enzymes, leading to GAG accumulation. Neurodegenerative MPS diseases exhibit cognitive decline, behavioural problems and shortened lifespan. We have characterised neuropathological changes in mouse models...

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Bibliographic Details
Main Authors: Wilkinson, Fiona L., Holley, Rebecca J., Langford-Smith, Kia J., Badrinath, Soumya, Liao, Aiyin, Langford-Smith, Alex, Cooper, Jonathan D., Jones, Simon A., Wraith, J. Ed, Wynn, Rob F., Merry, Catherine L. R., Bigger, Brian W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338781/
https://ncbi.nlm.nih.gov/pubmed/22558223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035787
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