Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice

The human 16p11.2 microdeletion is one of the most common gene copy number variations linked to autism, but the pathophysiology associated with this chromosomal abnormality is largely unknown. The 593 kb deletion contains the ERK1 gene and other genes that converge onto the ERK/MAP kinase pathway. P...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pucilowska, Joanna, Vithayathil, Joseph, Pagani, Marco, Kelly, Caitlin, Karlo, J. Colleen, Robol, Camilla, Morella, Ilaria, Gozzi, Alessandro, Brambilla, Riccardo, Landreth, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705960/
https://ncbi.nlm.nih.gov/pubmed/29934348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0515-17.2018
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