The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

Autism spectrum disorders are complex, highly heritable neurodevelopmental disorders affecting ∼1 in 100 children. Copy number variations of human chromosomal region 16p11.2 are genetically linked to 1% of autism-related disorders. This interval contains the MAPK3 gene, which encodes the MAP kinase,...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pucilowska, Joanna, Vithayathil, Joseph, Tavares, Emmanuel J., Kelly, Caitlin, Karlo, J. Colleen, Landreth, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605601/
https://ncbi.nlm.nih.gov/pubmed/25698753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4864-13.2015
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