Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia

We report that changes of phosphodiesterase-10A (PDE10A) can map widespread functional imbalance of basal ganglia circuits in a mouse model of DYT1 dystonia overexpressing mutant torsinA. PDE10A is a key enzyme in the catabolism of second messenger cAMP and cGMP, whose synthesis is stimulated by D1...

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Publicat a:J Neurosci
Autors principals: D'Angelo, Vincenza, Castelli, Valentina, Giorgi, Mauro, Cardarelli, Silvia, Saverioni, Ilaria, Palumbo, Francesca, Bonsi, Paola, Pisani, Antonio, Giampà, Carmela, Sorge, Roberto, Biagioni, Stefano, Fusco, Francesca R., Sancesario, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705690/
https://ncbi.nlm.nih.gov/pubmed/28115486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3207-15.2016
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