Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia

DYT1 dystonia is an early-onset, hyperkinetic movement disorder caused by a deletion in the gene TOR1A, which encodes the protein torsinA. Several lines of evidence show that in animal models of DTY1 dystonia, there is impaired basal dopamine (DA) release and enhanced acetylcholine tone. Clinically,...

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Vydáno v:Front Syst Neurosci
Hlavní autoři: Zimmerman, Chelsea N., Eskow Jaunarajs, Karen L., Meringolo, Maria, Rizzo, Francesca R., Santoro, Massimo, Standaert, David G., Pisani, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468415/
https://ncbi.nlm.nih.gov/pubmed/28659770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsys.2017.00043
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