Developmental Profile of the Aberrant Dopamine D2 Receptor Response in Striatal Cholinergic Interneurons in DYT1 Dystonia

BACKGROUND: DYT1 dystonia, a severe form of genetically determined human dystonia, exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence and variability remain unclear. METHODS AND RESULTS: We characterized the alterations in D2 dopamin...

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Hauptverfasser: Sciamanna, Giuseppe, Tassone, Annalisa, Martella, Giuseppina, Mandolesi, Georgia, Puglisi, Francesca, Cuomo, Dario, Madeo, Grazia, Ponterio, Giulia, Standaert, David George, Bonsi, Paola, Pisani, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166312/
https://ncbi.nlm.nih.gov/pubmed/21912682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024261
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