Cholinergic Dysfunction Alters Synaptic Integration between Thalamostriatal and Corticostriatal Inputs in DYT1 Dystonia

Projections from thalamic intralaminar nuclei convey sensory signals to striatal cholinergic interneurons. These neurons respond with a pause in their pacemaking activity, enabling synaptic integration with cortical inputs to medium spiny neurons (MSNs), thus playing a crucial role in motor function...

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Auteurs principaux: Sciamanna, Giuseppe, Tassone, Annalisa, Mandolesi, Georgia, Puglisi, Francesca, Ponterio, Giulia, Martella, Giuseppina, Madeo, Graziella, Bernardi, Giorgio, Standaert, David G., Bonsi, Paola, Pisani, Antonio
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471539/
https://ncbi.nlm.nih.gov/pubmed/22933784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0041-12.2012
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